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KMID : 0361020190620060355
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Korean Journal of Otolaryngology - Head and Neck Surgery
2019 Volume.62 No. 6 p.355 ~ p.360
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Two Cases of Seronegative Paraneoplastic Neurologic Syndrome with Opsoclonus Nystagmus
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Bae Seong-Hoon
Lee Jeon-Mi
Kim Sung-Huhn
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Abstract
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The dizziness associated with paraneoplastic neurologic syndrome is hard to diagnose clinically because the prevalence of disease is rare, and radiologic and serologic examination result may come out normal. Opsoclonus-myoclonus symdrome is a representative of classical paraneoplastic neurologic syndromes. In this paper, we report 2 cases of paraneoplastic neurologic syndromes with negative serologic auto-antibody test and no brain lesion on MRI. Both cases were eventually diagnosed through PET. Patients with opsoclonus-myoclonus type nystagmus should be evaluated for paraneoplastic neurologic syndrome even if their radiologic and serologic findings are normal.
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KEYWORD
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Myoclonus, Nystagmus, Opsoclonus-myoclonus syndrome, Paraneoplastic syndrome, neurologic
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